In today's digital world, businesses face an increasing number of complex cyber threats. As threat actors continuously evolve and amplify their attacks, finding a comprehensive and reliable Managed Detection and Response (MDR) service is crucial. An MDR service should not only detect threats but also promptly respond and mitigate their potential impact.

Advance Threat Detection is pivotal in the torchlight of cyber risk control. The purpose is to spot malicious activities on enterprise networks, devices, and systems before they can cause significant damage. However, the real challenge is not detecting threats but accurately distinguishing malicious activities from ordinary ones and deploying the appropriate response plan. Given the sophistication of present-day cyber threats, the scope of threat detection has evolved beyond simple malware detection—it now includes advanced persistent threats, zero-day exploits, insider threats, and other new-age threats.

For a business, the benefits of advanced threat detection and response are manifold. Primely, it reduces the time to detect and respond to threats, commonly known as 'dwell time'. Shorter dwell times are preferable as they limit the potential damage a threat actor can do. An effective MDR service promptly identifies threats and responds to them, minimizing the risk to an organization's security fabric and disruption to its operations.

Choosing an MDR service is a strategic decision that involves attention to several important factors. It starts with understanding your security requirements and ends with assessing the services' ability to meet them. A top-rated MDR service will provide a combination of expert security personnel, advanced artificial intelligence, and machine learning technologies along with a 24/7 cybersecurity operations center.

It is equally important to scrutinize the service's past performance and track record of mitigating threats. One could also rely on customer testimonials and third-party reviews to understand its delivery competency. The strategy should invariably be to select the service that provides tactical cybersecurity incident handling, from first discovery to remediation.

Furthermore, the best MDR service providers would ensure inclusion of threat hunting activities, which means they proactively look for signs of threats and traces of past compromises. With this, businesses can not only control the present threat landscape but also predict and prepare for the future.

In conclusion, given the evolving cyber threat landscape, a robust advanced threat detection and response service is indispensable for businesses. Choosing an MDR service provider that offers comprehensive threat detection, quick response, and strategic management can considerably strengthen the security posture of a firm, ensuring their operations and digital assets are safe against today's multifaceted cyber threats.