Amyloidosis, a rare and often life-threatening disease, occurs when a substance called amyloid builds up in the body's organs. Amyloid is an abnormal protein produced in the bone marrow, eventually deposited in various tissues and organs impairing their normal function. The disease can be localized, affecting a single body organ, or systemic, damaging multiple organs. Although amyloidosis can occur at any age, it is most frequently diagnosed in individuals between 60 and 70 years old.

Initial symptoms are commonly overlooked due to their non-specific nature, often leading to a delay in diagnosis and treatment. Thus, understanding the broad range of symptoms associated with amyloidosis is imperative.

One of the most common symptoms of systemic amyloidosis is fatigue. The excessive production and deposit of amyloids interfere with the body’s normal organ function, leading to diminished energy levels and chronic fatigue.

Weight loss is another significant symptom. Unexplained substantial weight loss, often coupled with poor appetite, can indicate the onset of the disease.

Amyloidosis can significantly affect the kidneys, leading to proteinuria, a condition marked by excess protein in urine. Other related symptoms might include edema or swelling in the legs and ankles due to fluid build-up resulting from kidney damage.

The disease can also affect the heart, causing restrictive cardiomyopathy, where the heart struggles to relax between beats. Symptoms can include shortness of breath, arrhythmia, fluid retention, and heart failure.

Digestive issues may also arise, with patients experiencing symptoms such as severe diarrhea or constipation, indicating amyloid deposits in the gastrointestinal system. Likewise, amyloidosis can affect the nervous system, with people experiencing numbness, tingling, or even pain in hands and feet, known as peripheral neuropathy.

Finally, amyloidosis can manifest on the skin with symptoms such as purpura - dark purplish skin patches often present around the eyes.

While assessing these symptoms, it is also important to consider the different types of amyloidosis – AL, AA, and hereditary – as each one could have slightly different patterns of symptom presentation.

People with prolonged, unaccounted symptoms resembling those of amyloidosis should consult a healthcare professional. If amyloidosis is suspected, performing laboratory tests, organ function assessments, and biopsies could confirm the diagnosis. Early detection and targeted treatments can help manage the symptoms and potentially slow the progression of this disease.

It's crucial to raise awareness about these symptoms of amyloidosis, as early diagnosis and intervention are imperative in managing this potentially fatal disease. Remember, these symptoms can also be associated with other conditions; hence, it's important not to jump to conclusions and always seek advice from healthcare professionals.