Axiron is messy to apply but it works well. My testosterone levels have increased tenfold. I no longer have depression and my sex drive is through the roof like it was before. While at first I was embarrassed talking to my doctor about the problem, I’m definitely glad I did. There was some irritation at first and I would get headaches, but that seems to have resolved itself. The only real problem is making sure I don’t get it on my clothes or my wife or anywhere else, because it gets everywhere before it has dried.